April 3rd, 2010 
The pathophysiology of lung cancer development is complicated and incompletely understood. The genes influenced in the pathogenesis of the cancer generate proteins involved in cell development and differentiation, apoptosis, tumor progression, cell cycle processes, angiogenesis, and immune regulation. Exposing these mechanisms ought to translate into novel means of risk stratification, early detection, prevention, and therapy.
The cancers are in general divided into small cell (SCLC) and non-small cell lung cancer (NSCLC).
Small cell lung cancer responds to radiotherapy and chemotherapy, and for that reason the treatment is extremely different from the other types. Malignant tumors arise most generally in response to repetitive carcinogenic stimuli, inflammation, or irritation. The mucosal lining is the most susceptible to injury, particularly at locations of bronchial bifurcation. The slow alteration of normal mucosal cells into malignant cells is a complex course.
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